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W. James Fleming

Publications and source records attributed to W. James Fleming.

43 records · Page 3Linked to original sources

Recovery of brain and plasma cholinesterase activities in ducklings exposed to organophosphorus pesticides

Brain and plasma cholinesterase (ChE) activities were determined for mallard ducklings ( Anas platyrhynchos ) exposed to dicrotophos and fenthion. Recovery rates of brain ChE did not differ between ducklings administered a single oral dose vs. a 2-week dietary dose of these organophosphates. Exposure to the organophosphates, followed by recovery of brain ChE, did not significantly affect the degree of brain ChE inhibition or the recovery of ChE activity at a subsequent exposure. Recovery of brain ChE activity followed the general model Y=a+b(logX) with rapid recovery to about 50% of normal, followed by a slower rate of recovery until normal ChE activity levels were attained. Fenthion and dicrotophos-inhibited brain ChE were only slightly reactivated in vitro by pyridine-2-aldoxime methiodide, which suggested that spontaneous reactivation was not a primary method of recovery of ChE activity. Recovery of brain ChE activity can be modeled for interpretation of sublethal inhibition of brain ChE activities in wild birds following environmental applications of organophosphates. Plasma ChE activity is inferior to brain ChE activity for environmental monitoring, because of its rapid recovery and large degree of variation among individuals.

Archives of Environmental Contamination and Toxico

Recovery of cholinesterase activity in five avian species exposed to dicrotophos, an organophosphorus pesticide

The responses of brain and plasma cholinesterase (ChE) activities were examined in mallard ducks, bobwhite quail, barn owls, starlings, and common grackles given oral doses of dicrotophos, an organophosphorus insecticide. Up to an eightfold difference in response of brain ChE activity to dicrotophos was found among these species. Brain ChE activity recovered to within 2 SD of normal within 26 days after being depressed 55 to 64%. Recovery of brain ChE activity was similar among species and followed the model Y = a + b (log 10 X ).

Pesticide Biochemistry and Physiology

Environmental metal residues in tissues of canvasbacks

Reduction and deterioration of habitat and high nest predation have contributed to the decline of the continental populations of canvasbacks (Aythya valisineria) (Trauger 1974). Environmental metal contaminants also may adversely affect reproduction and survival of waterfowl (Heinz 1974, 1976a,b, 1979; Finley and Stendell 1978). White et al. (1979) ex- amined canvasbacks from Chesapeake Bay in 1975 and 1976 and found low levels of lead, cadmium, and mercury in certain tissues. Low levels of mercury in canvasbacks have also been reported from Wisconsin (Kleinert and Degurse 1972) and Saskatchewan (Vermeer and Armstrong 1972). Stendell et al. (1977) found mercury residues in 6 of 34 canvasback eggs collected in 1972 and 1973. The objective of my study was to ascertain levels of mercury, lead, cadmium, and nickel in canvasbacks from the upper Mississippi River

Journal of Wildlife Management

Iatrogenic salt poisoning in captive sandhill cranes

Salt poisoning developed in captive sandhill cranes (Grus canadensis) when sea salt was added to normal drinking water to produce a sodium chloride concentration of 1%. Two of 18 cranes died and 2 were euthanatized when moribund. Muscle weakness, paresis, dyspnea, and depression were observed. Brain and serum sodium, serum uric acid,:and plasma osmolality values were abnormally high. Lesions were those of visceral gout, renal tubular necrosis, nephrosis, and skeletal muscle.necrosis.

Journal of the American Veterinary Medical Associa

DDE residues in young wood ducks (Aix sponsa) near a former DDT manufacturing plant

Breast muscle DDE residues were as high as 5.8 ppm wet-weight basis and 280 ppm lipid-weight basis in young wood ducks (Aix Sponsa) collected on Wheeler National Wildlife Refuge near a former DDT manufacturing plant in northern Alabama. The average DDE residue in wood ducks collected nearest the plant was 46 times background levels 74 km from the plant.

Pesticides Monitoring Journal

Influence of a local source of DDT pollution on statewide DDT residues in waterfowl wings, northern Alabama, 1978-79

Heavy DDT contamination resulting from a former DDT manufacturing plant in northern Alabama has influenced statewide averages of DDT, DDE, and TDE residues in duck wings tested in the National Pesticide Monitoring Program. In states where contaminant levels in duck wings are high, residue analyses of wings categorized by finer geographic subdivision may be useful in defining the areas of heaviest contamination.

Pesticides Monitoring Journal

Situation report: Heavy DDT contamination at Wheeler National Wildlife Refuge

A DDT manufacturing plant that operated on the Redstone Arsenal near Huntsville, Alabama discharged DDT-Iaden effluent from 1947 to 1970 into a creek on Wheeler National Wildlife Refuge. Seven to 9 years after the plant closed, high DDT, DDE, and DDD levels were reported in soils, river sediments, and fish in the area. Eleven of 27 mallards (Anas platyrhynchos) collected on the Refuge during February 1979 had carcass DDE residues that exceeded levels associated with eggshell thinning. DDE residues in a smaller number of mallards exceeded levels associated with egg breakage, poor hatchability, and abnormal hehavior and poor survival of offspring. Several avian species have disappeared from the Refuge since 1950, probably due to both industrial discharges of DDT from the plant and insecticidal use of DDT in the area. The contamination still presents a threat to herons, waterfowl, and raptors including occasional wintering or migrant eagles (Haliaeetus leucocephalus), and probably many other avian species. A maternity colony of endangered gray bats (Myotis grisescens) is also threatened by this contamination.

Proceedings of the Annual Conference of the Southe